Polynucleotides in Warwickshire
Polynucleotides – True Skin Regeneration at a Cellular Level
Polynucleotides represent one of the most advanced developments in regenerative skin medicine. Rather than simply hydrating the skin or adding volume, they work at a cellular and molecular level to repair, strengthen and regenerate skin tissue from within.
At Dr Hazel Skin Solutions in Long Itchington, near Leamington Spa, we offer treatment with PolyPhil® by Croma, a polynucleotide-based injectable designed to improve skin quality, thickness, elasticity and resilience.
This treatment is particularly valuable for fragile, crepey, inflamed or ageing skin, and for areas where traditional fillers or skin boosters may not be appropriate.
What Are Polynucleotides?
Polynucleotides are biopolymers derived from purified DNA fragments, sourced from salmon or freshwater fish. These DNA fragments are highly biocompatible with human tissue and have been shown to support cell repair and regeneration.
When injected into the skin, polynucleotides act as a biological scaffold, supporting damaged tissue and influencing the behaviour of skin cells, particularly fibroblasts, which are responsible for producing collagen and elastin.
Unlike dermal fillers:
Polynucleotides do not add volume
They do not change facial shape
They focus entirely on skin health and regeneration
How Do Polynucleotides Work?
Polynucleotides work through several complementary mechanisms:
Fibroblast stimulation
encouraging the production of new collagen and elastin
Improved skin thickness and density
strengthening fragile or thinning skin
Hydration at a cellular level
improving water retention without volumisation
Anti-inflammatory effects
calming redness and irritation
Protection against oxidative stress
supporting skin exposed to sun damage or environmental stress
This makes polynucleotides particularly effective for skin that is thin, crepey, damaged or inflamed, where traditional volumising treatments may be unsuitable.
Why Choose PolyPhil®?
PolyPhil® is a refined polynucleotide formulation that offers excellent versatility across different skin types and concerns.
The PolyPhil range (previously branded as PhilArt) includes products specifically designed for:
• Delicate areas such as the under-eye region
• General facial rejuvenation
• More advanced ageing, scarring or body indications
This allows treatment to be precisely tailored to the area being treated and the condition of the skin.
Treatment Areas
Polynucleotides can be used on multiple areas of the face and body, including:
Under-eye area (dark circles, fine lines, crepey texture)
Face
Neck
Décolletage
Hands
Acne scars
Stretch marks
They are particularly effective in areas where the skin is thin or fragile, and where other injectable treatments may carry higher risk.
Is Polynucleotide Treatment Right for Me?
Polynucleotides may be particularly suitable if you:
• Have thin, crepey or fragile skin
• Are concerned about skin quality rather than volume
• Want under-eye rejuvenation without filler
• Have inflammatory skin concerns such as redness or rosacea
• Prefer a regenerative, long-term approach to skin ageing
A full consultation with Dr Hazel will determine whether polynucleotides are the most appropriate treatment, or whether an alternative such as Sunekos, Profhilo, microneedling or Morpheus8 would better address your concerns.
Treatment Course and Maintenance
For optimal results, polynucleotide treatments are delivered as a course, allowing cumulative regeneration to occur.
Typical protocols include:
- PolyPhil or Plinest range – 3 to 4 treatments, spaced 3–4 weeks apart
- Plenhyage XL – 2 to 3 treatments, spaced 4 weeks apart
Skin quality continues to improve over time as collagen production increases.
To maintain results, a maintenance treatment every 6–9 months is usually recommended.
Results and Recovery
Polynucleotides work gradually. Unlike fillers, results are not immediate.
- Early improvements in hydration and skin comfort may be noticed within 2–4 weeks
- More visible changes in skin texture, thickness and elasticity develop over 8–12 weeks
- Results continue to evolve as collagen remodels
Downtime is minimal. You may notice small raised areas (blebs) at injection points immediately after treatment, which usually settle within a few hours and occasionally up to 24–48 hours.
Most patients return to normal activities the same day.
Get in Touch
We are always on hand to answer any questions you may have about our treatments.
Book a consultation
Led by Dr Hazel Parkinson, a multi-award-winning aesthetic doctor and dermatology specialist, Dr Hazel Skin Solutions focuses on natural, regenerative results supported by evidence-based science.
Dr Hazel’s extensive experience ensures your treatment plan is tailored precisely to your skin type, hormonal influences and lifestyle for the most effective results.
Frequently Asked Questions
Are polynucleotides the same as skin boosters?
No. While both improve skin quality, polynucleotides are considered a regenerative treatment, not simply a hydrator. They actively influence cell behaviour and tissue repair rather than just adding moisture.
Are polynucleotides the same as dermal filler?
No. Polynucleotides do not add volume, shape or lift. They do not alter facial contours and are not used for structural support.
Are polynucleotides suitable for the under-eye area?
Yes. Polynucleotides are particularly well suited to the under-eye area, where the skin is thin and delicate, and where traditional fillers may not be appropriate.
When will I see results?
Results develop gradually. Early improvements may be seen within 2–4 weeks, with optimal results visible at around 8–12 weeks following treatment
Is there any downtime?
Downtime is minimal. Small blebs or mild redness may be present immediately after treatment and usually settle within a few hours.
How long do results last?
Downtime is minimal. Small blebs or mild redness may be present immediately after treatment and usually settle within a few hours.
Can polynucleotides be combined with other treatments?
Yes. Polynucleotides are often used as part of a staged, holistic treatment plan, alongside microneedling, skin boosters, energy-based devices or injectables. Treatments are planned carefully and timed appropriately to support skin recovery and optimise results.